Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse.

@article{Daly2011ImpairedIA,
  title={Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse.},
  author={Donna M. Daly and Sung Jin Park and William C. Valinsky and Michael J Beyak},
  journal={The Journal of physiology},
  year={2011},
  volume={589 Pt 11},
  pages={
          2857-70
        }
}
Gastrointestinal vagal afferents transmit satiety signals to the brain via both chemical and mechanical mechanisms. There is indirect evidence that these signals may be attenuated in obesity. We hypothesized that responses to satiety mediators and distension of the gut would be attenuated after induction of diet induced obesity. Obesity was induced by feeding a high fat diet (60% kcal from fat). Low fat fed mice (10% kcal from fat) served as a control. High fat fed mice were obese, with… CONTINUE READING
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