Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene.

@article{Ichihara1995ImpairedI,
  title={Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene.},
  author={Masatoshi Ichihara and Tomoko Hara and Minoru Takagi and Lawrence Chinsoo Cho and Daniel M. Gorman and Atsushi Miyajima},
  journal={The EMBO journal},
  year={1995},
  volume={14 5},
  pages={939-50}
}
Interleukin-3 (IL-3) alone does not support hematopoietic colony formation of bone marrow cells from the A/J mouse. To elucidate the molecular lesion in A/J mice, we examined expression of the alpha and beta subunits of the IL-3 receptor (IL-3R). While IL-3R beta was normally expressed, IL-3R alpha was not detectable on the surface of A/J-derived cells by antibody staining. Genetic linkage analysis using recombinant inbred mouse strains between A/J and IL-3-responsive C57BL/6 indicated that the… CONTINUE READING