Impaired intellect and memory: a missing link between genetic risk and schizophrenia?

  title={Impaired intellect and memory: a missing link between genetic risk and schizophrenia?},
  author={Timothea Toulopoulou and Terry E. Goldberg and Irene Rebollo Mesa and Marco M. Picchioni and Fruhling V. Rijsdijk and Daniel Stahl and Stacey Shawn Cherny and Pak Sham and Stephen V Faraone and Ming T. Tsuang and Daniel R. Weinberger and Larry J. Seidman and Robin MacGregor Murray},
  journal={Archives of general psychiatry},
  volume={67 9},
CONTENT The DSM-IV concept of schizophrenia offers diagnostic reliability but etiologic and pathologic heterogeneity, which probably contributes to the inconsistencies in genetic studies. One solution is to identify intermediate phenotypes, "narrower" constructs of liability, that hypothetically share genetic risk with the disorder. Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia… CONTINUE READING
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