Impaired intellect and memory: a missing link between genetic risk and schizophrenia?

@article{Toulopoulou2010ImpairedIA,
  title={Impaired intellect and memory: a missing link between genetic risk and schizophrenia?},
  author={T. Toulopoulou and T. Goldberg and I. R. Mesa and M. Picchioni and F. Rijsdijk and D. Stahl and S. Cherny and P. Sham and S. Faraone and M. Tsuang and D. Weinberger and L. Seidman and R. Murray},
  journal={Archives of general psychiatry},
  year={2010},
  volume={67 9},
  pages={
          905-13
        }
}
  • T. Toulopoulou, T. Goldberg, +10 authors R. Murray
  • Published 2010
  • Medicine, Psychology
  • Archives of general psychiatry
  • CONTENT The DSM-IV concept of schizophrenia offers diagnostic reliability but etiologic and pathologic heterogeneity, which probably contributes to the inconsistencies in genetic studies. One solution is to identify intermediate phenotypes, "narrower" constructs of liability, that hypothetically share genetic risk with the disorder. Although a variety of candidate intermediate phenotypes have emerged, few have explicitly quantified the extent of their genetic overlap with schizophrenia… CONTINUE READING

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