Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.

@article{Broussard2012ImpairedIS,
  title={Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study.},
  author={Josiane L. Broussard and David A. Ehrmann and Eve Van Cauter and Esra Tasali and Matthew J. Brady},
  journal={Annals of internal medicine},
  year={2012},
  volume={157 8},
  pages={549-57}
}
BACKGROUND Insufficient sleep increases the risk for insulin resistance, type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral metabolic pathways. Yet, a direct link between sleep restriction and alterations in molecular metabolic pathways in any peripheral human tissue has not been shown. OBJECTIVE To determine whether sleep restriction results in reduced insulin sensitivity in subcutaneous fat, a peripheral tissue that plays a pivotal role in energy… CONTINUE READING

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