Impaired insulin signaling in an animal model of Niemann-Pick Type C disease.

@article{Ong2012ImpairedIS,
  title={Impaired insulin signaling in an animal model of Niemann-Pick Type C disease.},
  author={Qi-Rui Ong and Mei-Li Lim and Ching-ching Chua and Nam Sang Cheung and B S Wong},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={424 3},
  pages={482-7}
}
Studies have shown similarities between the histopathological characteristics of NPC and Alzheimer's disease (AD) including amyloid and tau pathologies. While dysfunction in insulin signaling was widely detected in AD brain, the function of insulin signaling proteins has not been examined in NPC disease. In this study, we have examined the expression and phosphorylation of proteins linked to the insulin signaling pathway in the brain of 9 weeks old NPC(nih) mice. Our results showed lower… CONTINUE READING