Impaired insulin sensitivity, insulin secretion, and glucose effectiveness predict future development of impaired glucose tolerance and type 2 diabetes in pre-diabetic African Americans: implications for primary diabetes prevention.

@article{Osei2004ImpairedIS,
  title={Impaired insulin sensitivity, insulin secretion, and glucose effectiveness predict future development of impaired glucose tolerance and type 2 diabetes in pre-diabetic African Americans: implications for primary diabetes prevention.},
  author={Kwame Osei and Scott Rhinesmith and Trudy R. Gaillard and Dara P. Schuster},
  journal={Diabetes care},
  year={2004},
  volume={27 6},
  pages={1439-46}
}
OBJECTIVE We examined the determinants of impaired glucose tolerance (IGT) and type 2 diabetes in first-degree relatives of African-American type 2 diabetic patients over 5-8 years (median 6). RESEARCH DESIGN AND METHODS A total of 81 healthy subjects (age 41.5 +/- 4.8 years; BMI 31.3 +/- 3.6 kg/m(2)) participated in the study. Each subject underwent an oral glucose tolerance test (OGTT) and a frequently sampled intravenous glucose tolerance test at baseline. Insulin sensitivity index (S(i… CONTINUE READING
48 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Pancreatic beta cell defects in gestational diabetes: implications for the pathogenesis and prevention of type 2 diabetes

  • TA Buchanan
  • J Clin Endocrinol Metab 86:989–
  • 2001
1 Excerpt

Similar Papers

Loading similar papers…