Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults

@article{Vauhkonen2000ImpairedIS,
  title={Impaired insulin secretion in non-diabetic offspring of probands with latent autoimmune diabetes mellitus in adults},
  author={Ilkka Vauhkonen and Leo Niskanen and Mikael Knip and Jorma Ilonen and E. Vanninen and Sakari Kainulainen and Matti Uusitupa and Markku Laakso},
  journal={Diabetologia},
  year={2000},
  volume={43},
  pages={69-78}
}
Aims/hypothesis. This study was undertaken to investigate metabolic and genetic characteristics of latent autoimmune diabetes in adults (LADA).¶Methods. We evaluated insulin secretory capacity with oral and intravenous glucose tolerance tests (early insulin response) and hyperglycaemic clamp (insulin secretory capacity) and the rates of whole body glucose uptake with the euglycaemic clamp, HLA-DQB1 genotypes (time-resolved fluorescence) and islet cell antibodies (ICA) (immunofluoresence) and… CONTINUE READING

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