Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

@article{Clocquet2000ImpairedIS,
  title={Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).},
  author={Astrid R Clocquet and Josephine M. Egan and Doris A. Stoffers and Denis C. Muller and Laurie Wideman and G A Chin and William L. Clarke and John B. Hanks and Joel Francis Habener and Dariush H Elahi},
  journal={Diabetes},
  year={2000},
  volume={49 11},
  pages={1856-64}
}
Diabetes resulting from heterozygosity for an inactivating mutation of the homeodomain transcription factor insulin promoter factor 1 (IPF-1) is due to a genetic defect of beta-cell function referred to as maturity-onset diabetes of the young 4. IPF-1 is required for the development of the pancreas and mediates glucose-responsive stimulation of insulin gene transcription. To quantitate islet cell responses in a family harboring a Pro63fsdelC mutation in IPF-1, we performed a five-step (1-h… CONTINUE READING
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