Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.

@article{Vollenweider1994ImpairedIS,
  title={Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans.},
  author={Peter Vollenweider and D Randin and Luc Tappy and Eric J{\'e}quier and Pascal Nicod and Urs Scherrer},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 6},
  pages={2365-71}
}
The sympathetic nervous system is an important regulatory mechanism of both metabolic and cardiovascular function, and altered sympathetic activity may play a role in the etiology and/or complications of obesity. In lean subjects, insulin evokes sympathetic activation and vasodilation in skeletal muscle. In obese subjects such vasodilation is impaired and, in turn, may contribute to insulin resistance. To examine the relationship between sympathetic and vasodilatory responses in skeletal muscle… CONTINUE READING

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