Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.

@article{Olofsson2009ImpairedIE,
  title={Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.},
  author={Charlotta S Olofsson and Joakim H{\aa}kansson and Albert Salehi and Martin Bengtsson and Juris Galvanovskis and Chris Partridge and Maria S{\"o}rhedeWinzell and Xiaojie Xian and Lena Eliasson and Ingmar Lundquist and Henrik Semb and Patrik Rorsman},
  journal={Endocrinology},
  year={2009},
  volume={150 7},
  pages={3067-75}
}
The neural cell adhesion molecule (NCAM) is required for cell type segregation during pancreatic islet organogenesis. We have investigated the functional consequences of ablating NCAM on pancreatic beta-cell function. In vivo, NCAM(-/-) mice exhibit impaired glucose tolerance and basal hyperinsulinemia. Insulin secretion from isolated NCAM(-/-) islets is enhanced at glucose concentrations below 15 mM but inhibited at higher concentrations. Glucagon secretion from pancreatic alpha-cells evoked… CONTINUE READING
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