Impaired insulin action on granulosa-lutein cells in women with polycystic ovary syndrome and insulin resistance.

@article{Fedorcsak2000ImpairedIA,
  title={Impaired insulin action on granulosa-lutein cells in women with polycystic ovary syndrome and insulin resistance.},
  author={Peter Fedorcsak and Ritsa Storeng and Per Olav Dale and Tom Tanbo and Thomas {\AA}byholm},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={2000},
  volume={14 5},
  pages={
          327-36
        }
}
We studied the in vitro response to insulin of granulosa-lutein cells derived from patients with polycystic ovary syndrome (PCOS) and clinically defined insulin resistance. Insulin sensitivity was assessed by continuous infusion of glucose with model assessment test (CIGMA). Insulin resistant (PCOS-IR; n = 8), noninsulin resistant (PCOS-NIR; n = 9) patients with PCOS, and women with tubal factor infertility (TF; n = 8) underwent controlled ovarian stimulation with long-term gonadotropin… CONTINUE READING

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