Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin.

@article{Kum2010ImpairedII,
  title={Impaired innate immune response and enhanced pathology during Citrobacter rodentium infection in mice lacking functional P-selectin.},
  author={Winnie W. S. Kum and Bernard C. Lo and Wanyin Deng and Hermann J. Ziltener and B. Brett Finlay},
  journal={Cellular microbiology},
  year={2010},
  volume={12 9},
  pages={
          1250-71
        }
}
The selectin family of adhesion molecules mediates recruitment of immune cells to sites of inflammation which is critical for host resistance against infection. To characterize the role of selectins in host defence against Citrobacter rodentium infection, wild-type (WT) mice and mice lacking P-selectin glycoprotein ligand-1 (PSGL-1), P-, E- and L-selectin were infected using a Citrobacter-induced colitis model. Infected mice lacking PSGL-1 or P-selectin showed a more pronounced morbidity… CONTINUE READING