Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease.

@article{Culpitt2003ImpairedIB,
  title={Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease.},
  author={Sarah V. Culpitt and Duncan Fraser Rogers and Pallav Shah and Carmen de Matos and Richard E K Russell and Louise E Donnelly and Peter J Barnes},
  journal={American journal of respiratory and critical care medicine},
  year={2003},
  volume={167 1},
  pages={
          24-31
        }
}
Chronic obstructive pulmonary disease (COPD) is characterized by inflammation of the respiratory tract in which macrophages are the predominant inflammatory cell and for which the efficacy of treatment with corticosteroids is controversial. We investigated the effect of dexamethasone on basal and interleukin (IL)-1beta or cigarette smoke media (CSM)-stimulated release of IL-8 and granulocyte macrophage-colony stimulating factor (GM-CSF) by bronchoalveolar lavage macrophages from cigarette… CONTINUE READING
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