Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.

@article{Wilcox2002ImpairedIO,
  title={Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.},
  author={Ryan A Wilcox and Dallas B. Flies and Hao Wang and Koji Tamada and A. J. Johnson and Larry R. Pease and Moses Rodriguez and Y. -K. Guo and Lieping Chen},
  journal={Cancer research},
  year={2002},
  volume={62 15},
  pages={4413-8}
}
Engagement of CD137 receptor by agonistic monoclonal antibodies (mAb) stimulates IFN-gamma production and eradicates established tumors in syngeneic mouse models. Using IFN-gamma-deficient mice or neutralizing mAb, we demonstrate that IFN-gamma is an absolute requirement for the antitumor effect of CD137 mAb. Despite progressive tumor growth in IFN-gamma-depleted mice, a fully competent CD8(+) cytolytic T cell (CTL) response developed in the lymph nodes. In addition, tumor cell sensitivity to… CONTINUE READING
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