Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope.

@article{Kaneko1997ImpairedIO,
  title={Impaired induction of cytotoxic T lymphocytes by antagonism of a weak agonist borne by a variant hepatitis C virus epitope.},
  author={Takashi Kaneko and Takashi Moriyama and Keiko Udaka and Kazumasa Hiroishi and Hiroto Kita and Hiroaki Okamoto and H. Yagita and Ko Okumura and Michio Imawari},
  journal={European journal of immunology},
  year={1997},
  volume={27 7},
  pages={1782-7}
}
An epitope that acted as a weak agonist in the cytotoxicity assay was identified as part of the capsid protein of a hepatitis C virus (HCV) variant. In a low concentration, the variant epitope also had a weak antagonistic effect. When a minute amount of this variant epitope was added to the culture for induction, it selectively attenuated the expansion of… CONTINUE READING