Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.

@article{Kracker2010ImpairedIO,
  title={Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.},
  author={Sven Kracker and Kohsuke Imai and Pauline Gard{\`e}s and Hans D. Ochs and Alain Fischer and Anne H Durandy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 51},
  pages={22225-30}
}
Ig class-switch recombination (CSR) is a region-specific process that exchanges the constant Ig heavy-chain region and thus modifies an antibody's effector function. DNA lesions in switch (S) regions are induced by activation-induced cytidine deaminase (AID) and uracil-DNA glycosylase 2 (UNG2), subsequently processed to DNA breaks, and resolved by either the classical nonhomologous end-joining pathway or the alternative end-joining pathway (XRCC4/DNA ligase 4- and/or Ku70/Ku80-independent and… CONTINUE READING