Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects.

@article{Hansen2012ImpairedIA,
  title={Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects.},
  author={Katrine Bagge Hansen and Tina Vilsb\oll and Jonatan Ising Bagger and Jens Juul Holst and Filip Krag Knop},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 4},
  pages={1363-70}
}
OBJECTIVE The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects… CONTINUE READING
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