Impaired in vitro growth of purified (CD34+) hematopoietic progenitors in human immunodeficiency virus-1 seropositive thrombocytopenic individuals

@inproceedings{Zauli1992ImpairedIV,
  title={Impaired in vitro growth of purified (CD34+) hematopoietic progenitors in human immunodeficiency virus-1 seropositive thrombocytopenic individuals},
  author={Giorgio Zauli and Maria Carla Re and Brian Richard Davis and L Sen and Giuseppe Visani and Luigi Gugliotta and Giuliano Furlini and Marco La Placa},
  year={1992}
}
In this report the role played by human immunodeficiency virus type-1 (HIV-1) in the pathogenesis of HIV-1-related thrombocytopenia was investigated. CD34+ hematopoietic stem/progenitor cells were purified from the bone marrow (BM) of HIV-l(+) thrombocytopenic patients, HIV-1(+) nonthrombocytopenic individuals, HlV-l(-) patients with immune thrombocytopenic purpura, and HlV-l(-) normal donors. CD34+ cells from HIV-l(+) thrombocytopenic individuals alone showed a reduced capacity to give rise to… CONTINUE READING