Impaired in vitro growth of purified (CD34+) hematopoietic progenitors in human immunodeficiency virus-1 seropositive thrombocytopenic individuals.

@article{Zauli1992ImpairedIV,
  title={Impaired in vitro growth of purified (CD34+) hematopoietic progenitors in human immunodeficiency virus-1 seropositive thrombocytopenic individuals.},
  author={G. Zauli and M. C. Re and B. Davis and L. Sen' and G. Visani and L. Gugliotta and G. Furlini and M. La Placa},
  journal={Blood},
  year={1992},
  volume={79 10},
  pages={
          2680-7
        }
}
  • G. Zauli, M. C. Re, +5 authors M. La Placa
  • Published 1992
  • Biology, Medicine
  • Blood
  • In this report the role played by human immunodeficiency virus type-1 (HIV-1) in the pathogenesis of HIV-1-related thrombocytopenia was investigated. CD34+ hematopoietic stem/progenitor cells were purified from the bone marrow (BM) of HIV-1(+) thrombocytopenic patients, HIV-1(+) nonthrombocytopenic individuals, HIV-1(-) patients with immune thrombocytopenic purpura, and HIV-1(-) normal donors. CD34+ cells from HIV-1(+) thrombocytopenic individuals alone showed a reduced capacity to give rise to… CONTINUE READING
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