Impaired immune and acute-phase responses in interleukin-6-deficient mice

@article{Kopf1994ImpairedIA,
  title={Impaired immune and acute-phase responses in interleukin-6-deficient mice},
  author={Manfred Kopf and Heinz Baumann and Giulia Freer and Marina A. Freudenberg and Marinus C. Lamers and Tadamitsu Kishimoto and Rolf Martin Zinkernagel and Horst Bluethmann and Georges K{\"o}hler},
  journal={Nature},
  year={1994},
  volume={368},
  pages={339-342}
}
lNTERLEUKIN-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To… 

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