Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels

Abstract

Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD. Here, we provide evidence that indicates that this decrease is associated with the AD-linked angiopathy. While wild-type mice of different ages show upregulated cerebral neuroglobin expression upon whole-body… (More)
DOI: 10.1002/1873-3468.12651

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Cite this paper

@inproceedings{Acker2017ImpairedHT, title={Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels}, author={Zo{\"{e} P. Van Acker and Evi Luyckx and Wendy Van Leuven and Eva Geuens and Peter Paul De Deyn and Debby Van Dam and Sylvia Dewilde}, booktitle={FEBS letters}, year={2017} }