Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression

@article{Wichniak2004ImpairedH,
  title={Impaired hypothalamic-pituitary-adrenocortical (HPA) system is related to severity of benzodiazepine withdrawal in patients with depression},
  author={Adam Wichniak and Hans Brunner and Marcus Ising and Francisco Pedrosa Gil and Florian Holsboer and Elisabeth Friess},
  journal={Psychoneuroendocrinology},
  year={2004},
  volume={29},
  pages={1101-1108}
}
A concatenation of data indicates that the pathogenesis of depression is related to an increased production and secretion of corticotropin-releasing hormone (CRH). Benzodiazepines profoundly suppress the basal and stress-related activation of the hypothalamic-pituitary-adrenocortical (HPA) system and discontinuation of these drugs results in rebound activation. We therefore investigated whether the extent of HPA system dysregulation is related to the severity of benzodiazepine withdrawal in… Expand
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