Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice.

@article{Jiang2009ImpairedHA,
  title={Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice.},
  author={Xue Jiang and Jing Wang and Tian Tian Luo and Qian Li},
  journal={Psychoneuroendocrinology},
  year={2009},
  volume={34 3},
  pages={317-31}
}
Our previous studies have demonstrated that mice with reduced or absent serotonin transporter (SERT+/- and SERT-/- mice, respectively) are more sensitive to stress relative to their SERT normal littermates (SERT+/+ mice). The aim of the present study was to test the hypothesis that the hypothalamic-pituitary-adrenal (HPA) axis and its feedback regulation are impaired in these mice. The function and gene expression of several components in the HPA axis and its feedback regulation in SERT… CONTINUE READING

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