Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice.

@article{Larson2006ImpairedHL,
  title={Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice.},
  author={John R. Larson and Ruth E Jessen and Tolga Uz and Ahmet Dirim Arslan and Murat Kurtuncu and Marta Imbesi and Hari Manev},
  journal={Neuroscience letters},
  year={2006},
  volume={393 1},
  pages={23-6}
}
The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and learning-dependent behavior. In field CA1 of hippocampal slices from wild-type mice, theta burst stimulation induced robust and stable long-term potentiation that was smaller and… CONTINUE READING
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