Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression.

@article{Cordido1996ImpairedGH,
  title={Impaired growth hormone secretion in obese subjects is partially reversed by acipimox-mediated plasma free fatty acid depression.},
  author={Fernando Cordido and Roberto Pein{\'o} and A. Pe{\~n}alva and Clara V. Alvarez and Felipe F F Casanueva and Carlos Di{\'e}guez},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 3},
  pages={914-8}
}
GH secretion in response to provocative stimuli is blunted in obese patients. On the other hand, increases in plasma free fatty acids (FFA) inhibit the GH response to a variety of stimuli, and FFA levels in plasma are increased with obesity. To ascertain whether FFA might be responsible for the GH secretory alterations of obesity, we studied spontaneous and stimulated GH secretion in 31 obese patients after FFA reduction by acipimox, a lipid-lowering drug devoid of serious side-effects. Each… CONTINUE READING

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