Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.

@article{Nishida2013ImpairedGM,
  title={Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.},
  author={Takashi Nishida and Satoshi Kubota and Eriko Aoyama and Masaharu Takigawa},
  journal={Osteoarthritis and cartilage},
  year={2013},
  volume={21 5},
  pages={
          700-9
        }
}
OBJECTIVE Hypertrophy-like changes are often observed in chondrocytes during the development of osteoarthritis (OA). These changes play a crucial part in the OA-associated cartilage degradation and osteophyte formation. However, the pathogenesis leading to such changes is still unknown. In this study, we investigated the mechanism by which these hypertrophy-like changes are induced from the viewpoint of impaired glycolytic metabolism. METHODS The effect of sodium fluoride (NaF) on glycolytic… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

role in initiation and progression of cartilage degeneration? Osteoarthritis Cartilage 2012;20:223e32

  • PM vanderKraan, van den Berg WB. Chondrocyte hypertrophy, osteoarthritis
  • T. Nishida et al. / Osteoarthritis and Cartilage…
  • 2013

Similar Papers

Loading similar papers…