Impaired glucose tolerance in the R6/1 transgenic mouse model of Huntington's disease.

@article{Josefsen2008ImpairedGT,
  title={Impaired glucose tolerance in the R6/1 transgenic mouse model of Huntington's disease.},
  author={Knud Josefsen and Mette Damgaard Nielsen and K. H. J\orgensen and Troels G Bock and Anne N\orrem\olle and Sven Asger S\orensen and Bjarke Naver and L. Hasholt},
  journal={Journal of neuroendocrinology},
  year={2008},
  volume={20 2},
  pages={165-72}
}
Previous reports have highlighted a possible link between Huntington's disease (HD) and diabetes mellitus (DM), but the association has not been characterised in detail. A transgenic mouse model for HD, the R6/2 mouse, also develops diabetes. In the present study, we examined the R6/1 mouse, which carries a shorter CAG repeat than the R6/2 mouse, and found that, although not diabetic, the mice showed several signs of impaired glucose tolerance. First, following i.p. glucose injection, the blood… CONTINUE READING
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