Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state.

  title={Impaired glucose tolerance in low-carbohydrate diet: maybe only a physiological state.},
  author={Rennan de Oliveira Caminhotto and Fabio Bessa Lima},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={305 12},
  • R. O. CaminhottoF. Lima
  • Published 15 December 2013
  • Biology
  • American journal of physiology. Endocrinology and metabolism
to the editor: in the recent work of Bielohuby et al. ([1][1]) published in this journal, the authors discussed the hypothesis that the restriction of carbohydrates, substituted by the high consumption of fats, induces a state of glucose intolerance and insulin resistance in rats, which was 

Almond “Appetizer” Effect on Glucose Tolerance Test (GTT) Results

A low-calorie almond “appetizer” showed promise as an option for decreasing postprandial hyperglycemia in individuals with prediabetes or isolated 1-hour postpr andial hyperglucosemia in glucose-intolerant individuals without diabetes.

The mystery of the ketogenic diet: benevolent pseudo-diabetes

In mice, benevolent (starvation) pseudo-diabetes may counteract type 2 diabetes or its complications, and use of the KD and rapamycin is indicated for a similar spectrum of diseases, including Alzheimer’s disease and cancer.

Ketogenic diet in combination with voluntary exercise impacts markers of hepatic metabolism and oxidative stress in male and female Wistar rats.

The data highlight that ketogenic diet feeding combined with exercise improved hepatic oxidative stress, suppressed markers of de novo lipogenesis, increased markers of mitochondrial content vs western diet feeding and merits further investigation.

Carbohydrate Intake Prior to Oral Glucose Tolerance Testing

An OGTT performed in a research setting without adequate carbohydrate intake at the evening meal prior to the OGTT mimicked the loss of first-phase insulin release seen in early type 1 and type 2 diabetes.



A review of low-carbohydrate ketogenic diets

In response to the emerging epidemic of obesity in the United States, a renewal of interest in alternative diets has occurred, especially in diets that limit carbohydrate intake. Recent research has

Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet.

It is suggested that maintenance on low-carbohydrate, ketogenic diets negatively affects glucose homeostasis, an effect that is rapidly reversed upon cessation of the diet.

Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets.

The data show that lack of dietary carbohydrates leads to glucose intolerance and insulin resistance in rats despite causing a reduction in fasting glucose and insulin concentrations, and argues against a beneficial effect of LC-HF diets on glucose and diabetes metabolism, at least under physiological conditions.

Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents

The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children’s weight loss.

Mechanisms modifying glucose oxidation in diabetes mellitus

It seems likely that longer term effects of fatty acids on this and other aspects of glucose metabolism could be important in the development of insulin resistance in diabetes mellitus in man.

The glucose-fatty acid cycle. Relationship between glucose utilization in muscle, fatty acid oxidation in muscle and lipolysis in adipose tissue.

There is a vital need for the rate of production of a fuel to be regulated precisely in relation to its rate of utilization and for the rates of production and utilization of all fuels to be satisfactorily integrated.

Niacin stimulates adiponectin secretion through the GPR109A receptor.

Results demonstrate that the GPR109A receptor plays an important role in the dual regulation of adiponectin secretion and lipolysis.

Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

It is reported that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous and specific inhibitor of class I histone deacetylases (HDACs), and treatment of mice with βOHB conferred substantial protection against oxidative stress.

Survival in starvation.

  • G. Cahill
  • Medicine
    The American journal of clinical nutrition
  • 1998