Impaired germ cell development in the testes of immature rats with neonatal hypothyroidism.

@article{Simorangkir1997ImpairedGC,
  title={Impaired germ cell development in the testes of immature rats with neonatal hypothyroidism.},
  author={David R. Simorangkir and Nigel G. M. Wreford and David M De Kretser},
  journal={Journal of andrology},
  year={1997},
  volume={18 2},
  pages={
          186-93
        }
}
The induction of neonatal hypothyroidism from day 1 to day 25 postpartum using 6-propyl-2-thiouracil (PTU) resulted in a 45% and 77% reduction of testis weight on days 20 and 30, respectively, and an increase in Sertoli cell number. The present study evaluated the effect of neonatal hypothyroidism on the developing germ cell population during the first 30 days postnatally. Qualitative and quantitative studies using the optical disector method were undertaken on the testes of control and… CONTINUE READING
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