Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.

@article{Pihlajamki2000ImpairedFF,
  title={Impaired free fatty acid suppression during hyperinsulinemia is a characteristic finding in familial combined hyperlipidemia, but insulin resistance is observed only in hypertriglyceridemic patients.},
  author={Jussi Pihlajam{\"a}ki and Leena Karjalainen and Pauli Karhap{\"a}{\"a} and Ilkka Vauhkonen and Markku Laakso},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 1},
  pages={164-70}
}
Insulin resistance has been associated with hypertriglyceridemia, combined hyperlipidemia, and familial combined hyperlipidemia (FCHL). Whether all FCHL patients with different types of dyslipidemia have low insulin sensitivity has not been evaluated. We measured insulin sensitivity by the hyperinsulinemic euglycemic clamp with indirect calorimetry in 110 healthy controls and in 105 nondiabetic, FCHL family members: in 50 without dyslipidemia, in 19 with hypercholesterolemia (total cholesterol… CONTINUE READING
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Impaired insulinstimulated glucose oxidation and free fatty acid suppression in patients with familial combined hyperlipidemia: a precursor defect for dyslipidemias?Arterioscler

L Karjalainen, J Pihlajamäki, P Karhapa ̈ä, M. Laakso
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