Impaired fear extinction in mice lacking protease nexin-1.

  title={Impaired fear extinction in mice lacking protease nexin-1.},
  author={Marita Meins and Cyril Herry and Christian M{\"u}ller and St{\'e}phane Ciocchi and Eliza Moreno and Andreas L{\"u}thi and Denis Monard},
  journal={The European journal of neuroscience},
  volume={31 11},
The serine protease inhibitor protease-nexin-1 (PN-1) has been shown to modulate N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic currents and NMDAR-dependent long-term potentiation of synaptic transmission. Here, we analysed the role of PN-1 in the acquisition and extinction of classical auditory fear conditioning, two distinct forms of learning that both depend on NMDAR activity in the amygdala. Immunostaining revealed that PN-1 is expressed throughout the amygdala, primarily in gamma… CONTINUE READING


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