Impaired facial emotion recognition in a ketamine model of psychosis

@article{Ebert2012ImpairedFE,
  title={Impaired facial emotion recognition in a ketamine model of psychosis},
  author={Andreas Ebert and Ida Sybille Haussleiter and Georg Juckel and Martin Br{\"u}ne and Patrik Roser},
  journal={Psychiatry Research},
  year={2012},
  volume={200},
  pages={724-727}
}
OBJECTIVE Social cognitive disabilities are a common feature in schizophrenia. Given the role of glutamatergic neurotransmission in schizophrenia-related cognitive impairments, we investigated the effects of the glutamatergic NMDA receptor antagonist ketamine on facial emotion recognition. METHODS Eighteen healthy male subjects were tested on two occasions, one without medication and one after administration with subanesthetic doses of intravenous ketamine. Emotion recognition was examined… 
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References

SHOWING 1-10 OF 35 REFERENCES
Impairment in the specificity of emotion processing in schizophrenia.
TLDR
Differential impairment was seen in patients with schizophrenia for processing emotional faces, although the nonemotional task proved harder for both groups, and emotion discrimination tests could augment the neurobehavioral evaluation of patients.
Impairments of facial emotion recognition and theory of mind in methamphetamine abusers
TLDR
Impairments in cognitive flexibility are correlated with impairments in facial emotion recognition and ToM within MA abusers, lending further support to the assertion that the capacity to identify emotions from facial expression and infer mental state of others is impaired in MA abusers.
Emotion recognition in individuals at clinical high-risk for schizophrenia.
TLDR
A trait deficit and an involvement of the amygdala in the pathology of ultra high-risk states are suggested and specific impairments in emotion recognition may be apparent in people at clinical high- risk for schizophrenia before the full expression of psychotic illness.
Ketamine alters neural processing of facial emotion recognition in healthy men: an fMRI study
TLDR
It is predicted that ketamine would produce reduced activity in limbic and visual brain regions involved in emotion processing, and increased activity in dorsal regions of the prefrontal cortex and cingulate gyrus, both associated with cognitive processing and, putatively, with emotion regulation.
Emotion recognition deficit in schizophrenia: association with symptomatology and cognition
TLDR
The findings lend support to the concept that emotion recognition is uniquely associated in schizophrenia with core symptomatology and cognitive domains, as well as with healthy control subjects on computerized tasks of emotion and age recognition.
Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study
TLDR
An association between impaired extrastriate visual processing of facial fear and negative symptoms, which may underlie the previously reported difficulties of patients with negative symptoms in the recognition of facialFear is indicated.
Emotion recognition and genetic vulnerability to schizophrenia.
  • B. Bediou, F. Asri, +4 authors I. Tazi
  • Psychology, Medicine
    The British journal of psychiatry : the journal of mental science
  • 2007
TLDR
Impaired performance in healthy siblings and time stability in patients provides evidence of impairment of facial emotion recognition as an actual phenotype of schizophrenia.
Facial emotion recognition in schizophrenia:When and why does it go awry?
TLDR
Patients with schizophrenia demonstrate abnormalities in early visual encoding of facial features that precedes the ERP response typically associated with facial affect recognition, which suggests that affect recognition deficits, at least for happy and sad discrimination, are secondary to faulty structural encoding of faces.
Facial emotion recognition in Chinese with schizophrenia at early and chronic stages of illness
TLDR
Chinese patients with schizophrenia, in both the first-episode and chronic stages, performed significantly worse than their control counterparts on overall facial emotion recognition, with specific impairment in identifying surprise, fear and disgust.
Emotion recognition, ‘theory of mind,’ and social behavior in schizophrenia
  • M. Brüne
  • Medicine, Psychology
    Psychiatry Research
  • 2005
TLDR
Impaired executive functioning did, however, only partially account for the deficits in social perception and social cognition in schizophrenia, which significantly contributes to the understanding of social behavioral problems in schizophrenia.
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