Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.

@article{Dharancy2005ImpairedEO,
  title={Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.},
  author={S{\'e}bastien Dharancy and Mathilde Malapel and Gabriel Perlemuter and Tania A Roskams and Yang Cheng and Laurent Dubuquoy and Philippe Podevin and Filom{\'e}na Conti and Val{\'e}rie Canva and David Philippe and Luc Gambiez and Philippe Mathurin and J. Paris and Kristina Schoonjans and Yvon Calmus and Stanislas Pol and Johan Auwerx and Pierre Desreumaux},
  journal={Gastroenterology},
  year={2005},
  volume={128 2},
  pages={334-42}
}
BACKGROUND AND AIMS Liver inflammation, fibrosis, and dyslipidemia are common features in patients with chronic hepatitis C virus (HCV) infection. Because peroxisome proliferator-activated receptor alpha (PPARalpha) is highly expressed in the liver and is involved in the regulation of lipid metabolism and inflammation, we sought to determine whether HCV infection may locally impair PPARalpha expression and activity. METHODS PPARalpha expression was investigated in liver biopsy specimens of 86… CONTINUE READING
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