Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality.

@article{Miura2006ImpairedEO,
  title={Impaired expression of importin/karyopherin beta1 leads to post-implantation lethality.},
  author={Katsutaka Miura and Kumiko Yoshinobu and Takashi Imaizumi and Kyoko Haruna and Yoichi Miyamoto and Yoshihiro Yoneda and Naomi Nakagata and Masatake Araki and Taihei Miyakawa and Ken-ichi Yamamura and Kimi Araki},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={341 1},
  pages={132-8}
}
Importin beta1 (Impbeta)/karyopherin beta1 (Kpnb1) mediates the nuclear import of a large variety of substrates. This study aimed to investigate the requirement for the Kpnb1 gene in mouse development, using a gene trap line, B6-CB-Ayu8108(GtgeoIMEG) (Ayu8108(geo)), in which the trap vector was inserted into the promoter region of the Kpnb1 gene, but in reverse orientation of the Kpnb1 gene. Ayu8108(geo/geo) homozygous embryos could develop to the blastocyst stage, but died before embryonic day… CONTINUE READING