Impaired expression of CD28 on T cells in hairy cell leukemia.

  title={Impaired expression of CD28 on T cells in hairy cell leukemia.},
  author={Lisette van de Corput and J. H. Frederik Falkenburg and Michel G. D. Kester and Roel Willemze and Johanna C Kluin-Nelemans},
  journal={Clinical immunology},
  volume={93 3},
T cells from patients with active hairy cell leukemia (HCL), a chronic B cell malignancy, show poor proliferation in response to allogeneic peripheral blood mononuclear cells (PBMC). In order to study the T cell dysfunction, the expression of several adhesion and costimulatory molecules was analyzed by flow cytometry. Circulating T cells from HCL patients showed increased percentages of CD28(-) in all T cell subsets. In some patients the percentage of CD28(-) T cells within the CD4(+) subset… CONTINUE READING