Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.

@article{Sassa2013ImpairedEP,
  title={Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.},
  author={Takayuki Sassa and Yusuke Ohno and Shotaro Suzuki and Toshifumi Nomura and Chieko Nishioka and Toshiki Kashiwagi and Taisuke Hirayama and Masashi Akiyama and R. Hakamada Taguchi and Hiroshi Shimizu and Shigeyoshi Itohara and Akio Kihara},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 14},
  pages={
          2787-96
        }
}
The sphingolipid backbone ceramide (Cer) is a major component of lipid lamellae in the stratum corneum of epidermis and has a pivotal role in epidermal barrier formation. Unlike Cers in other tissues, Cers in epidermis contain extremely long fatty acids (FAs). Decreases in epidermal Cer levels, as well as changes in their FA chain lengths, cause several cutaneous disorders. However, the molecular mechanisms that produce such extremely long Cers and determine their chain lengths are poorly… CONTINUE READING
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