Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.

@article{Zeiher1995ImpairedEV,
  title={Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia.},
  author={Andreas Michael Zeiher and Thomas Krause and Volker Schaechinger and Jan Minners and Ernst Moser},
  journal={Circulation},
  year={1995},
  volume={91 9},
  pages={2345-52}
}
BACKGROUND The release of endothelium-derived relaxing factors has been shown experimentally to be of pivotal importance for the maintenance of coronary blood flow during increased demand. In humans with coronary atherosclerosis, endothelial vasodilator dysfunction is not confined only to epicardial conductance vessels but may also extend into the coronary microcirculation. We therefore tested the hypothesis that endothelial vasodilator dysfunction of the coronary resistance vasculature is… CONTINUE READING

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