Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P.

@article{Egashira1995ImpairedEV,
  title={Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P.},
  author={Kensuke Egashira and Satoru Suzuki and Yoshitaka Hirooka and Hisashi Kai and Masaru Sugimachi and Tsutomu Imaizumi and Akira Takeshita},
  journal={Hypertension},
  year={1995},
  volume={25 2},
  pages={201-6}
}
Hypertensive patients have impaired endothelium-dependent coronary vasodilation evoked with acetylcholine. The aim of this study was to examine whether the impaired endothelium-dependent dilation of coronary arteries is related to a specific abnormality of the muscarinic receptor that mediates the effects of acetylcholine. Responses of the large epicardial and resistance coronary arteries were assessed in seven hypertensive patients (mean arterial pressure, 106 +/- 14 mm Hg) and seven control… CONTINUE READING