Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats.

@article{Heygate1995ImpairedER,
  title={Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats.},
  author={K M Heygate and Ian G Lawrence and Melissa A. Bennett and Herbert Thurston},
  journal={British journal of pharmacology},
  year={1995},
  volume={116 8},
  pages={3251-9}
}
1. Previous studies have shown that endothelium-dependent relaxation in the aorta of spontaneously diabetic bio bred rats (BB) is impaired. 2. We have investigated noradrenaline (NA) contractility, endothelium-dependent acetylcholine (ACh) and bradykinin (BK) relaxation, and endothelium-independent sodium nitroprusside (SNP) relaxation in mesenteric resistance arteries of recent onset BB rats and established insulin treated BB rats, compared to their age-matched non diabetic controls. 3. There… CONTINUE READING
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