Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen.

  title={Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen.},
  author={Sean P. Didion and Curt D. Sigmund and Frank M. Faraci},
  volume={31 3},
  pages={760-4; discussion 765}
BACKGROUND AND PURPOSE Chronic hypertension is a risk factor for carotid vascular disease and stroke. Mechanisms that account for alterations in carotid and cerebral vascular function during hypertension are poorly defined and based almost exclusively on studies in the spontaneously hypertensive rat, a model in which hypertension has an unknown etiology and in which the genetic background is dissimilar to the most commonly used normotensive control, the Wistar-Kyoto rat. METHODS In this study… CONTINUE READING
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