Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.

@article{Christensen2016ImpairedEB,
  title={Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1.},
  author={Pernille M. Christensen and Catherine H. Liu and Steven L Swendeman and Hideru Obinata and Klaus Qvortrup and Lars Bo Nielsen and Timothy Hla and Annarita Di Lorenzo and Christina Christoffersen},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2016},
  volume={30 6},
  pages={2351-9}
}
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn suppresses vascular leak. Increased vascular permeability is a hallmark of inflammation. The purpose of this study was to explore the relationships between vascular leakage in ApoM deficiency and S1P1… CONTINUE READING