Impaired endocytosis in proximal tubule from subchronic exposure to cadmium involves angiotensin II type 1 and cubilin receptors

@inproceedings{SantoyoSnchez2013ImpairedEI,
  title={Impaired endocytosis in proximal tubule from subchronic exposure to cadmium involves angiotensin II type 1 and cubilin receptors},
  author={Mitzi Paola Santoyo-S{\'a}nchez and Jos{\'e} Pedraza-Chaverri and Eduardo Molina-Jij{\'o}n and Laura Arreola-Mendoza and Rafael Rodr{\'i}guez-Mu{\~n}{\'o}z and Olivier Barbier},
  booktitle={BMC nephrology},
  year={2013}
}
BACKGROUND Chronic exposure to low cadmium (Cd) levels produces urinary excretion of low molecular weight proteins, which is considered the critical effect of Cd exposure. However, the mechanisms involved in Cd-induced proteinuria are not entirely clear. Therefore, the present study was designed to evaluate the possible role of megalin and cubilin (important endocytic receptors in proximal tubule cells) and angiotensin II type 1 (AT1) receptor on Cd-induced microalbuminuria. METHODS Four… CONTINUE READING