Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.

@article{Dascombe1989ImpairedEO,
  title={Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.},
  author={Michael J Dascombe and Alice Hardwick and R A Lefeuvre and Nancy J. Rothwell},
  journal={International journal of obesity},
  year={1989},
  volume={13 3},
  pages={367-73}
}
Interleukin-1 beta (IL-1 beta) is an endogenous peptide which induced fever (1.8 degrees C rise in colonic temperature) when injected interacerebroventricularly (i.c.v., 80ng human recombinant IL-1 beta) into conscious lean rats. IL-1 beta also stimulated resting oxygen consumption (VO2) by 38 percent, in vitro thermogenic activity (mitochondrial GDP binding) of brown adipose tissue (BAT) by almost two-fold, and blood flow to brown fat (assessed from the distribution of radiolabelled… CONTINUE READING
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