Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder.

@article{Lissek2009ImpairedDF,
  title={Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder.},
  author={Shmuel Lissek and Stephanie J. Rabin and Dana J McDowell and Sharone Dvir and Daniel E. Bradford and Marilla F Geraci and Daniel S. Pine and Christian Grillon},
  journal={Behaviour research and therapy},
  year={2009},
  volume={47 2},
  pages={111-8}
}
Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted. One conditioning perspective proposes associative-learning deficits characterized by deficient safety learning among PD patients. The current study of PD assesses acquisition and retention of discriminative aversive conditioning using a fear-potentiated startle paradigm. This paradigm was chosen for its specific capacity to independently… CONTINUE READING
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