Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.

@article{Baldn2006ImpairedDO,
  title={Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow.},
  author={{\'A}ngel Bald{\'a}n and Liming Pei and Richard Lee and Paul Tarr and Rajendra K. Tangirala and Michael S Weinstein and Joy Frank and Andrew C. Li and Peter Tontonoz and Peter A. Edwards},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 10},
  pages={2301-7}
}
OBJECTIVE The lungs of Abcg1-/- mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facilitating the efflux of cholesterol from macrophages to high-density lipoprotein (HDL) and other exogenous sterol acceptors. Based on these observations, we investigated whether loss of ABCG1 affects foam cell deposition in the artery wall and the development of atherosclerosis. METHODS AND RESULTS Bone marrow from… CONTINUE READING

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