Impaired dendritic cell maturation and increased TH2 responses in PIR-B−/− mice

  title={Impaired dendritic cell maturation and increased TH2 responses in PIR-B−/− mice},
  author={Azusa Ujike and Kazuhiko Takeda and Akira Nakamura and Shin Ebihara and Kenichi Akiyama and Toshiyuki Takai},
  journal={Nature Immunology},
Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B−/− mice had an increased number of peritoneal B1 cells. Splenic PIR-B−/− B2 cells were constitutively activated and proliferated much more than those from wild-type mice upon B cell receptor ligation. T helper type 2 (TH2)-prone humoral responses were augmented in PIR-B−/− mice upon immunization with T-dependent antigens… CONTINUE READING
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