Impaired delay but normal trace eyeblink conditioning in PLCbeta4 mutant mice.

@article{Kishimoto2001ImpairedDB,
  title={Impaired delay but normal trace eyeblink conditioning in PLCbeta4 mutant mice.},
  author={Yasushi Kishimoto and Moritoshi Hirono and Takashi Sugiyama and Shigenori Kawahara and Kazuki Nakao and Masahiro Kishio and Motoya Katsuki and Tohru Yoshioka and Yutaka Kirino},
  journal={Neuroreport},
  year={2001},
  volume={12 13},
  pages={2919-22}
}
To elucidate the functional role of phospholipase Cbeta4 (PLCbeta4), which is highly expressed in the Purkinje cells of the rostral cerebellum, cerebellar long-term depression (LTD) and delay and trace eyeblink conditioning were investigated in PLCbeta4-deficient mice. Rostral cerebellar LTD and delay eyeblink conditioning were severely impaired, whereas trace eyeblink conditioning was not. These results indicate that PLCbeta4 is essential for LTD in the rostral cerebellum and delay… CONTINUE READING

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