Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin.

@article{Kato2005ImpairedDO,
  title={Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin.},
  author={Takahiro A Kato and Nobuo Okahashi and Shinji Kawai and Takafumi Kato and Hiroaki Inaba and Ichijiro Morisaki and Atsuo Amano},
  journal={Journal of periodontology},
  year={2005},
  volume={76 6},
  pages={941-50}
}
BACKGROUND Gingival overgrowth (GO) is a serious adverse effect associated with the administration of phenytoin (PHT), with PHT-induced GO characterized by a massive accumulation of extracellular matrix components, especially collagen, in gingival connective tissues. However, the etiology of such collagen accumulation is still largely unknown. We examined the effects of PHT on the collagen degradation process leading to collagen accumulation in human gingival fibroblasts (HGF). METHODS HGFs… CONTINUE READING