Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

@article{Nakayama2003ImpairedDO,
  title={Impaired degradation of inhibitory subunit of NF-$\kappa$B (I$\kappa$B) and $\beta$-catenin as a result of targeted disruption of the $\beta$-TrCP1 gene},
  author={K. Nakayama and S. Hatakeyama and S. Maruyama and A. Kikuchi and K. Onoé and R. Good},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={8752 - 8757}
}
β-TrCP1 (also known as Fbw1a or FWD1) is the F-box protein component of an Skp1/Cul1/F-box (SCF)-type ubiquitin ligase complex. Although biochemical studies have suggested that β-TrCP1 targets inhibitory subunit of NF-κB(IκB) proteins and β-catenin for ubiquitylation, the physiological role of β-TrCP1 in mammals has remained unclear. We have now generated mice deficient in β-TrCP1 and shown that the degradation of IκBα and IκBβ is reproducibly, but not completely, impaired in the cells of these… Expand

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