Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells

Abstract

Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect remains limited. The present study sought to understand the molecular genetic characteristics of cholangiocarcinoma related to EGFR, with emphasis on… (More)
DOI: 10.1186/1471-2407-12-179

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Cite this paper

@inproceedings{Gui2012ImpairedDF, title={Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells}, author={Anping Gui and Akira Kobayashi and Hiroaki Motoyama and Masato Kitazawa and Michiko Takeoka and Shinichi Miyagawa}, booktitle={BMC Cancer}, year={2012} }