Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice.

@article{Helyes2009ImpairedDM,
  title={Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice.},
  author={Zsuzsanna Helyes and Erika Pint{\'e}r and Katalin S{\'a}ndor and Kriszti{\'a}n Elekes and Agnes B{\'a}nv{\"o}lgyi and D{\'a}niel Keszthelyi and E. – Szoke and D{\'a}niel M{\'a}rton T{\'o}th and Zolt{\'a}n S{\'a}ndor and L{\'a}szl{\'o} Kereskai and G{\'a}bor Pozsgai and Jeremy P. Allen and Piers C. Emson and Adrienn Markovics and J{\'a}nos Szolcs{\'a}nyi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 31},
  pages={13088-93}
}
We have shown that somatostatin released from activated capsaicin-sensitive nociceptive nerve endings during inflammatory processes elicits systemic anti-inflammatory and analgesic effects. With the help of somatostatin receptor subtype 4 gene-deleted mice (sst(4)(-/-)), we provide here several lines of evidence that this receptor has a protective role in a… CONTINUE READING